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. 1980 Jun 5;285(5764):378-82.
doi: 10.1038/285378a0.

Analysis and prediction of protein beta-sheet structures by a combinatorial approach

F E Cohen, M J Sternberg, W R Taylor

Analysis and prediction of protein beta-sheet structures by a combinatorial approach

F E Cohen et al. Nature. .

Abstract

Analysis of beta-sheet sandwiches (for example immunoglobulin domains) suggests an algorithm that successfully predicts the tertiary fold of these proteins from their sequence and secondary structure. We propose tertiary structures for beta 2-microglobulin and an HLA-B7 antigen fragment. Topological rules are presented that markedly reduce the number of folds for proteins in which a-helices pack against a parallel beta-sheet.

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