Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Jun;19(6):977-84.
doi: 10.1016/0090-6980(80)90130-6.

Lidocaine increases prostacyclin in the rat

L C Casey, M C Armstrong, J R Fletcher, P W Ramwell

Lidocaine increases prostacyclin in the rat

L C Casey et al. Prostaglandins. 1980 Jun.

Abstract

In the rat, the effect of intravenous lidocaine was evaluated on plasma prostacyclin concentration as well as the concentration of prostacyclin in aortic ring incubation chambers and in the effluent of isolated perfused lungs. Prostacyclin was assayed using a radioimmunoassay for its stable product 6-Keto PGF1 alpha. Lidocaine in therapeutic doses (2 mg/kg) will significantly increase 6-Keto PGF1 alpha in plasma as well as in aortic ring incubation chambers and in the effluent of isolated perfused lungs when compared to saline treated controls.

PubMed Disclaimer

LinkOut - more resources