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. 1980 May;77(5):2546-50.
doi: 10.1073/pnas.77.5.2546.

Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae

D Gallwitz, I Sures

Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae

D Gallwitz et al. Proc Natl Acad Sci U S A. 1980 May.

Abstract

The complete nucleotide sequence of the actin gene from Saccharomyces cerevisiae has been determined. The coding region is interrupted by a 304-base-pair intervening sequence that is located within the triplet coding for amino acid 4. DNA sequences of the intron-exon junctions are similar to those found in higher eukaryotes and can be aligned such that the intron starts with the dinucleotide 5'-G-T-3' and ends with 5'-A-G-3'. Regions fo homology within the sequences upstream from the initiation codon and those following the termination codon have been detected between the yeast iso-1-cytochrome c gene and the actin gene. As deduced from the nucleotide sequence, yeast actin has 374 amino acid residues. Its primary structure, especially the NH2-terminal third of the protein, is highly conserved during evolution.

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