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Review
. 1980:31:29-34.
doi: 10.1146/annurev.me.31.020180.000333.

Hemoglobin A Ic and diabetes mellitus

R J Koenig, A Cerami
Review

Hemoglobin A Ic and diabetes mellitus

R J Koenig et al. Annu Rev Med. 1980.

Abstract

Hemoglobin A Ic is produced when glucose reacts nonenzymatically with the NH2-termini of Hb A beta chains and then undergoes an Amadori rearrangement. The concentration of Hb A Ic measured at any given time reflects a patient's mean blood glucose level for the preceding weeks to months. Infrequent measurements of Hb A Ic can therefore be used to assess long-term carbohydrate control in outpatient diabetics. In addition, the synthesis of Hb A Ic may represent a model reaction to explain the pathogenesis of many of the sequelae of chronic diabetes. Nonenzymatic glycosylation reactions may also underlie some of the changes ascribed to normal aging.

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