doi: 10.1084/jem.152.1.151.
Clonal nature of the immune response. II. The effect of immunization on clonal commitment
- PMID: 6995551
- PMCID: PMC2185905
- DOI: 10.1084/jem.152.1.151
Item in Clipboard
Clonal nature of the immune response. II. The effect of immunization on clonal commitment
J Exp Med.
.
Abstract
An inbred strain can produce several hundred different anti-group A carbohydrate (GAC) antibodies, as analyzed by isoelectric focusing. However, each individual mouse produces the bulk of its anti-GAC antibody as only one or two different spectrotypes, which appear to be randomly chosen. By using adoptive transfer techniques, we have observed that clonal commitment occurs very early in immunization, sometimes even before immunization, and thus does not result from competition among B cells for antigen. X
Similar articles
-
The clonal origin of cells contributing to successive phases of a cyclical immune response.Eur J Immunol. 1975 Oct;5(10):684-9. doi: 10.1002/eji.1830051007. Eur J Immunol. 1975. PMID: 11993335
-
Influence of antigenic competition on the development of antibody-forming cell clones.Clin Exp Immunol. 1977 Feb;27(2):328-34. Clin Exp Immunol. 1977. PMID: 300313 Free PMC article.
-
Immune competence of hereditarily asplenic mice.Immunology. 1974 Aug;27(2):167-78. Immunology. 1974. PMID: 4214128 Free PMC article.
-
Immune response against the T-independent antigen alpha (1----3) dextran. II. Occurrence of B gamma memory cells in the course of immunization with the native polysaccharide is T cell dependent.Eur J Immunol. 1984 Jun;14(6):578-85. doi: 10.1002/eji.1830140616. Eur J Immunol. 1984. PMID: 6203758
-
The B cell specificity repertoire: its relationship to definable subpopulations.Transplant Rev. 1975;24:41-83. doi: 10.1111/j.1600-065x.1975.tb00165.x. Transplant Rev. 1975. PMID: 49962 Review. No abstract available.
Cited by
-
The B cell repertoire revealed by major histocompatibility complex-specific helper T cells. I. Frequencies of a genetically defined V region marker among mitogen- and T helper cell-reactive B lymphocytes in normal and immunized mice.J Exp Med. 1984 Apr 1;159(4):1253-69. doi: 10.1084/jem.159.4.1253. J Exp Med. 1984. PMID: 6200567 Free PMC article.
-
Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae.J Exp Med. 1984 Aug 1;160(2):386-97. doi: 10.1084/jem.160.2.386. J Exp Med. 1984. PMID: 6381634 Free PMC article.
-
Analysis of human anti-diphtheria antibodies by isoelectric focusing: evidence for restricted clonal heterogeneity of anti-fragment A antibodies.Infect Immun. 1981 Mar;31(3):1132-7. doi: 10.1128/iai.31.3.1132-1137.1981. Infect Immun. 1981. PMID: 7228398 Free PMC article.
-
Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.J Exp Med. 1987 Feb 1;165(2):531-45. doi: 10.1084/jem.165.2.531. J Exp Med. 1987. PMID: 3102673 Free PMC article.
-
Construction of an extended three-dimensional idiotope map by electron microscopic analysis of idiotope-anti-idiotope complexes.Proc Natl Acad Sci U S A. 1987 Jul;84(14):4984-8. doi: 10.1073/pnas.84.14.4984. Proc Natl Acad Sci U S A. 1987. PMID: 3496600 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
