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. 1980 Oct 15;36(10):1149-50.
doi: 10.1007/BF01976092.

Inactivation of yeast glucose-6-P dehydrogenase by aspirin

P F Han, G Y Han, H C McBay, J Johnson Jr

Inactivation of yeast glucose-6-P dehydrogenase by aspirin

P F Han et al. Experientia. .

Abstract

Glucose-6-P dehydrogenase is irreversibly inactivated by treatment with Na salts of aspirin. Kinetic data show that 1 molecule of aspirin reacts with each active unit when the enzyme is inactivated. The rate of inactivation is enhanced with increasing pH but is reduced in the presence of glucose-6-P or NADP+. Na salicylate fails to inactivate the enzyme.

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References

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