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. 1980 Oct 9;287(5782):504-9.
doi: 10.1038/287504a0.

Isolation of a yeast centromere and construction of functional small circular chromosomes

L Clarke, J Carbon

Isolation of a yeast centromere and construction of functional small circular chromosomes

L Clarke et al. Nature. .

Abstract

The centromeric DNA (CEN3) from yeast chromosome III has been isolated on a 1.6 kilobase-pair segment of DNA located near the centromere-linked CDC10 locus of Saccharomyces cerevisiae. When present on a plasmid carrying a yeast chromosomal replicator, CEN3 enables that plasmid to function as a chromosome both mitotically and meiotically. Minichromosomes containing CEN3 are stable in mitosis and segregate as ordinary yeast chromosomes in the first and second meiotic divisions.

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