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Clinical Trial
. 1980 Oct;64(10):766-9.
doi: 10.1136/bjo.64.10.766.

Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration

L M Collum, A Benedict-Smith, I B Hillary
Clinical Trial

Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration

L M Collum et al. Br J Ophthalmol. 1980 Oct.

Abstract

The results of a randomised double-blind clinical trial of 3% acyclovir and 0.5% idoxuridine (IDU) ophthalmic ointments in 60 patients with corneal dendritic ulceration are presented. Ulcers in all 30 patients treated with acyclovir healed compared with 22 (76%) of 29 patients treated with IDU (P < 0.01). Patients treated with acyclovir healed more rapidly (average 4.4 days) than those who received IDU (average 9.2 days) (P < 0.01). No serious side effects were observed, though transient stinging was recorded in 8 patients receiving acyclovir and in 2 patients receiving IDU. Other side effects in the IDU treated group were watering in 2 patients and superficial punctate erosions in 6 patients.

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