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. 1978 Aug 15;34(8):1042-3.
doi: 10.1007/BF01915335.

Selective activation of noradrenergic neurons in the brainstem and spinal cord of young spontaneously hypertensive rats

K Nakamura, K Nakamura

Selective activation of noradrenergic neurons in the brainstem and spinal cord of young spontaneously hypertensive rats

K Nakamura et al. Experientia. .

Abstract

In young spontaneously hypertensive rats (SHR), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) activities were examined in the brainstem nuclei. Activation of noradrenergic neurons in the locus coeruleus, A2 and spinal intermediolateral cell areas, resulting in enhanced sympathetic nervous activity in the periphery, initiates hypertension. Adrenergic neurons, unchanged in these and A1 cell areas of young SHR, are not involved in the development of hypertension in SHR.

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