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. 1980 Aug;33(8):895-9.
doi: 10.7164/antibiotics.33.895.

Have deoxystreptamine aminoglycoside antibiotics the same binding site on bacterial ribosomes?

F Le Goffic, M L Capmau, F Tangy, E Caminade
Free article

Have deoxystreptamine aminoglycoside antibiotics the same binding site on bacterial ribosomes?

F Le Goffic et al. J Antibiot (Tokyo). 1980 Aug.
Free article

Abstract

(3H) Tobramycin was used as a probe to determine the relationship between the structure of aminoglycoside antibiotics and their ability to remove this drug from its higher affinity binding site on the ribosome. The dissacharide moieties (neamine, tobramine, gentamine) appeared to have a common binding site, whereas the kanosamine, garosamine and ribose moieties determined the specificity of this binding. Amikacin and butikacin behaved in an anomalous manner in spite of their close structural relationship to tobramycin.

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