A controlled trial of a combination of chloroquine with paracetamol in the treatment of acute malaria in a semi-immune population

Abstract

A clinial trial comparing a single dose of a fixed drug combination containing chloroquine and paracetamol with chloroquine and paracetamol given as separate tablets has been conducted among 154 patients seen in the Endemic Disease Clinic of the Lagos University Teaching Hospital and at two other clinics in Nigeria. There was no statistically significant difference in the preference between the different types of prescription among the sujects in the two groups. However, a greater degree of parasite clearance was achieved sooner in those who received the fixed drug combination taken in a single or in only two doses than among those whose therapy extended over 3 days or longer using separate tablets of chloroquine and paracetamol.