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. 1980 Jul;77(7):4170-4.
doi: 10.1073/pnas.77.7.4170.

A specific transcription factor that can bind either the 5S RNA gene or 5S RNA

H R Pelham, D D Brown

A specific transcription factor that can bind either the 5S RNA gene or 5S RNA

H R Pelham et al. Proc Natl Acad Sci U S A. 1980 Jul.

Abstract

5S ribosomal RNA specifically inhibits transcription of cloned repeating units of 5S DNA in a nuclear extract of Xenopus oocytes. The inhibition can be explained by the interaction of 5S RNA with a transcription factor that binds specifically to a control region located within the 5S RNA gene. This transcription factor is identical to an abundant cytoplasmic protein that is known to be complexed with 5S RNA in immature Xenopus oocytes. Thus the presence of large amounts of this protein in these cells can account for both the high rate of synthesis and the subsequent storage of 5S RNA to ribosome synthesis.

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References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Biochim Biophys Acta. 1970 Nov 12;224(1):99-113 - PubMed
    1. Dev Biol. 1971 Feb;24(2):143-65 - PubMed
    1. Nature. 1971 Oct 22;233(5321):561-4 - PubMed
    1. Eur J Biochem. 1972 Feb;25(3):535-43 - PubMed

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