Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1980 Oct;39(5):524-5.
doi: 10.1136/ard.39.5.524.

Reduced prostacyclin activity in systemic lupus erythematosus

B A McVerry, S J Machin, H Parry, A H Goldstone
Case Reports

Reduced prostacyclin activity in systemic lupus erythematosus

B A McVerry et al. Ann Rheum Dis. 1980 Oct.

Abstract

When fresh rabbit aorta is incubated with plasma, prostacyclin, a potent inhibitor of platelet aggregation, is normally released. Plasma obtained from 2 patients with systemic lupus erythematosus (SLE) inhibited prostacyclin activity, while plasma from 22 other patients with SLE and 40 normal control subjects showed normal activity. Absence of prostacyclin activity did not appear to correlate with the clinical severity of the underlying disease. The possible association of this finding and the presence of thrombotic lesions in both patients is discussed.

PubMed Disclaimer

References

    1. JAMA. 1968 Dec 2;206(10):2315-7 - PubMed
    1. Lancet. 1977 Jan 1;1(8001):18-20 - PubMed
    1. Nature. 1976 Oct 21;263(5579):663-5 - PubMed
    1. Lancet. 1978 Oct 21;2(8095):871-2 - PubMed
    1. Blood. 1979 Feb;53(2):244-50 - PubMed

Publication types