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Review
. 1980 Oct;10 Suppl 2(Suppl 2):343S-346S.
doi: 10.1111/j.1365-2125.1980.tb01820.x.

Use of non-steroidal anti-inflammatory drugs in the treatment of pain in cancer

V Ventafridda, C Fochi, D De Conno, E Sganzerla
Review

Use of non-steroidal anti-inflammatory drugs in the treatment of pain in cancer

V Ventafridda et al. Br J Clin Pharmacol. 1980 Oct.

Abstract

1 Prostaglandins may precipitate or exacerbate pain and they may be produced by several tumours. 2 Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis and may also inhibit bone metastases and enhance immune responses. 3 NSAIDs alone or in association with narcotics or psychotropics may not only afford the best pain relief in neoplastic disease, but also modify the progress of the tumour. 4 The effect of NSAIDs on the gastrointestinal tract is generally adverse.

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