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. 1980 Oct;30(1):125-8.
doi: 10.1128/iai.30.1.125-128.1980.

Biosynthesis of the K99 surface antigen is repressed by alanine

F K de Graaf, P Klaasen-Boor, J E van Hees

Biosynthesis of the K99 surface antigen is repressed by alanine

F K de Graaf et al. Infect Immun. 1980 Oct.

Abstract

The amino acid alanine induced a direct and specific repression of the biosynthesis of the K99 surface antigen in Escherichia coli strains harboring the K99 plasmid. In minimal medium with 0.5% glucose, 1 mM L-alanine was sufficient to reduce the K99 production by about 95%. The low production of the K99 antigen by strains growing on commercially available nutrient media seemed to be a result of the inhibitory effect alanine on the K99 biosynthesis.

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