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. 1981 Jan;145(1):644-6.
doi: 10.1128/jb.145.1.644-646.1981.

Escherichia coli K-12 clones that overproduce dam methylase are hypermutable

G E Herman, P Modrich

Escherichia coli K-12 clones that overproduce dam methylase are hypermutable

G E Herman et al. J Bacteriol. 1981 Jan.

Abstract

A strain of Escherichia coli K-12 that overproduces dam methylase 50-fold was found to be hypermutable, and mutations which resulted in loss of excess methylase activity restored mutation frequencies to wild-type levels. These results are consistent with involvement of this deoxyribonucleic acid methylase in mismatch correction.

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