doi: 10.1007/BF00268051.
Recognition of two initiation codons for the synthesis of phage fd gene 2 protein
- PMID: 7007816
- DOI: 10.1007/BF00268051
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Recognition of two initiation codons for the synthesis of phage fd gene 2 protein
Mol Gen Genet.
1980.
Abstract
Bacteriophage fd gene 2 protein was specifically labeled with radioactive amino acids and was isolated from membranous cell structures as an apparently homogenous protein. Amino acid sequence analysis revealed that the protein was initiated at two distinct AUG codons close to the ribosome binding site. The two resulting translation products were found to begin with a deformylated methionine residue. Initiation at the first signal was used for 90% of the chains and at the second signal for 10% of the sequenced molecules. The use of one or the other chain start may influence functions of gene 2 protein.
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