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Comparative Study
. 1978 Sep;12(3):173-6.
doi: 10.1111/j.1399-3011.1978.tb02882.x.

betah-endorphin: antidiuretic effects in rats

L F Tseng, H H Loh, C H Li
Comparative Study

betah-endorphin: antidiuretic effects in rats

L F Tseng et al. Int J Pept Protein Res. 1978 Sep.

Abstract

Human beta-endorphin (betah-EP) inhibits urine flow in rats. This antidiuretic effect of the peptide occurs after intravenous and intraventricular injections. Intravenously, betah-EP is 24 times more potent than morphine. Intraventricularly, betah-EP is 24 times more potent than morphine. Intraventricularly, betah-EP is effective at doses (0.45 microgram) which have no antidiuretic activity when injected intravenously. This fact suggests that one site of the antidiuretic action of betah-endorphin may be in the central nervous system. Animals tolerant to morphine are also tolerant to the antidiuretic effects of betah-endorphin.

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