A brief review of cartilage and controlling factors in chondrocranial morphogenesis

Abstract

It is evident that chondrocyte determination is an example of cellular aging. This possible leads to the erroneous view that chondrocytes have a "weak" genetic control mechanism. If such was the case, chondrocranial growth and development would be a very "shaky" process indeed. It is recognized however that chondrocranial growth is under predominantly genetic and tissue interaction influence especially during the early phase of growth. These control factors plus other epigenetic and local environmental influences are responsible for the harmonious growth of the chondrocranium.