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. 1981 Feb;78(2):852-5.
doi: 10.1073/pnas.78.2.852.

Release of 7-methylguanine residues from alkylated DNA by extracts of Micrococcus luteus and Escherichia coli

J Laval, J Pierre, F Laval

Release of 7-methylguanine residues from alkylated DNA by extracts of Micrococcus luteus and Escherichia coli

J Laval et al. Proc Natl Acad Sci U S A. 1981 Feb.

Abstract

Cell extracts from Micrococcus luteus release both free 3-methyladenine and free 7-methylguanine from alkylated DNA. The glycosylase activity responsible for the liberation of 7-methylguanine is not 3-methyladenine-DNA glycosylase, which, when purified, does not liberate it. Furthermore, the heat inactivation rates of the two enzymatic activities are different. The release of 7-methylguanine by chemical depurination of ethanol-soluble oligonucleotides has been ruled out. A similar activity releasing 7-methylguanine is also found in Escherichia coli.

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