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. 1981 May 22;212(4497):937-8.
doi: 10.1126/science.7015504.

Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes

M Baudry, M C Bundman, E K Smith, G S Lynch

Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes

M Baudry et al. Science. .

Abstract

Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.

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