doi: 10.1126/science.7015512.
Prostacyclin: a potent antimetastatic agent
- PMID: 7015512
- DOI: 10.1126/science.7015512
Item in Clipboard
Prostacyclin: a potent antimetastatic agent
Science.
.
Abstract
Metastasis is the principal cause of failures to cure human cancers. Prostacyclin is a powerful antimetastatic agent against B16 amelanotic melanoma cells. This effect, which may result from the platelet antiaggregatory action of prostacyclin, is potentiated by a phosphodiesterase inhibitor. Inhibitors of prostacyclin synthesis increase metastasis. Prostacyclin and agents that may increase endogenous prostacyclin production or prolong its activity are suggested as new antimetastatic agents.
Similar articles
-
Control of tumor growth and metastasis with prostacyclin and thromboxane synthetase inhibitors: evidence for a new antitumor and antimetastatic agent (BAY g 6575).Prog Clin Biol Res. 1982;89:295-331. Prog Clin Biol Res. 1982. PMID: 7051034 No abstract available.
-
Prostacyclin and its analogues: antimetastatic effects and mechanisms of action.Cancer Metastasis Rev. 1994 Dec;13(3-4):349-64. doi: 10.1007/BF00666104. Cancer Metastasis Rev. 1994. PMID: 7712596 Review.
-
Tumor cell-platelet aggregation: induced by cathepsin B-like proteinase and inhibited by prostacyclin.Science. 1982 Aug 6;217(4559):540-2. doi: 10.1126/science.7046053. Science. 1982. PMID: 7046053
-
Antimetastatic action of the prostacyclin analog iloprost in the mouse.Clin Exp Metastasis. 1989 Nov-Dec;7(6):671-8. doi: 10.1007/BF01753677. Clin Exp Metastasis. 1989. PMID: 2476273
-
Effects of prostacyclin analogues in in vivo tumor models.Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:901-8. Adv Prostaglandin Thromboxane Leukot Res. 1991. PMID: 1705084 Review.
Cited by
-
Comparison of metastatic cell lines derived from a murine mammary tumour, and reduction of metastasis by heparin.Clin Exp Metastasis. 1988 Nov-Dec;6(6):463-71. doi: 10.1007/BF01784377. Clin Exp Metastasis. 1988. PMID: 3409560
-
The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis.Int J Gastrointest Cancer. 2002;32(1):23-30. doi: 10.1385/IJGC:32:1:23. Int J Gastrointest Cancer. 2002. PMID: 12630766
-
Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1.Neoplasia. 2010 Mar;12(3):244-53. doi: 10.1593/neo.91690. Neoplasia. 2010. PMID: 20234818 Free PMC article.
-
Nafazatrom: clonogenic in-vitro assessment of activity against human malignancies.Invest New Drugs. 1984;2(1):7-11. doi: 10.1007/BF00173781. Invest New Drugs. 1984. PMID: 6469500
-
Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted?Evid Based Complement Alternat Med. 2018 Sep 9;2018:7931849. doi: 10.1155/2018/7931849. eCollection 2018. Evid Based Complement Alternat Med. 2018. PMID: 30271455 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
