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. 1981 Jun 12;212(4500):1270-2.
doi: 10.1126/science.7015512.

Prostacyclin: a potent antimetastatic agent

K V Honn, B Cicone, A Skoff

Prostacyclin: a potent antimetastatic agent

K V Honn et al. Science. .

Abstract

Metastasis is the principal cause of failures to cure human cancers. Prostacyclin is a powerful antimetastatic agent against B16 amelanotic melanoma cells. This effect, which may result from the platelet antiaggregatory action of prostacyclin, is potentiated by a phosphodiesterase inhibitor. Inhibitors of prostacyclin synthesis increase metastasis. Prostacyclin and agents that may increase endogenous prostacyclin production or prolong its activity are suggested as new antimetastatic agents.

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