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. 1981 Mar;32(1):48-50.

Effect of physostigmine on Plasmodium falciparum in culture

E Hempelmann, A R Dluzewski
  • PMID: 7015639

Effect of physostigmine on Plasmodium falciparum in culture

E Hempelmann et al. Tropenmed Parasitol. 1981 Mar.

Abstract

Human erythrocytes contain 7 electrophoretically different alpha-naphthyl acetate esterases. Their solubility properties indicate that 5 are present in the erythrocyte cytoplasm and 2 are tightly bound to the stroma; the stroma-bound esterases can be inhibited by 10(-5) M physostigmine. No additional physostigmine-sensitive enzymes were detectable in Plasmodium falciparum-infected cells. Addition of physostigmine to malaria parasites in culture killed the parasites rapidly.

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