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Clinical Trial
. 1981 Apr;43(4):436-42.
doi: 10.1038/bjc.1981.64.

A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma

N M Bleehen, C R Wiltshire, P N Plowman, J V Watson, J R Gleave, A E Holmes, W S Lewin, C S Treip, T D Hawkins
Free PMC article
Clinical Trial

A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma

N M Bleehen et al. Br J Cancer. 1981 Apr.
Free PMC article

Abstract

The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No significant differences were seen between the median survivals of patients in the 2 control radiation groups and that of the third group in which oral misonidazole at a dose of 3 g/m2 preceded each of 4 weekly radiation doses. Possible reasons why no improvement was seen are discussed in detail.

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