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. 1981 Apr;78(4):2155-8.
doi: 10.1073/pnas.78.4.2155.

Enzymatic reduction of protein-bound methionine sulfoxide

N Brot, L Weissbach, J Werth, H Weissbach

Enzymatic reduction of protein-bound methionine sulfoxide

N Brot et al. Proc Natl Acad Sci U S A. 1981 Apr.

Abstract

An enzyme that catalyzes the reduction of methionine sulfoxide residues in ribosomal protein L12 has been partially purified from Escherichia coli extracts. Methionine sulfoxide present in oxidize [Met]enkephalin is also reduced by the purified enzyme. The enzyme is different from a previously reported E. coli enzyme that catalyzes the reduction of methionine sulfoxide to methionine [Ejiri, S. I., Weissbach, H. & Brot, N. (1980) Anal. Biochem. 102, 393--398]. Extracts of rat tissues, Euglena gracilis, Tetrahymena pyriformis, HeLa cells, and spinach also can catalyze the reduction of methionine sulfoxide residues in protein.

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References

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