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. 1981 Jan;17(1):83-90.
doi: 10.1111/j.1399-0039.1981.tb00670.x.

Influence of HLA matching in cadaveric renal transplantation: experience from one Scandiatransplant center

E Thorsby, T Moen, B G Solheim, D Albrechtsen, A Jakobsen, J Jervell, S Halvorsen, A Flatmark

Influence of HLA matching in cadaveric renal transplantation: experience from one Scandiatransplant center

E Thorsby et al. Tissue Antigens. 1981 Jan.

Abstract

The outcome of 461 prospectively HLA-A, -B and -C typed and 193 prospectively HLA-DR typed cadaveric kidney transplants in one center was followed. We found a significant beneficial effect on graft survival both of HLA-A and -B as well as of HLA-DR matching between donor and recipient, while no effects of HLA-C compatibility could be detected. The effect of HLA-DR matching was clearly more pronounced than that of HLA-A and -B matching, and a possible influence of matching for HLA-A and -B could only be seen in the HLA-DR mismatched combinations. Pretransplant blood transfusions were associated with an increased graft survival only in patients receiving HLA-DR mismatched transplants. We conclude that major emphasis should be laid on obtaining HLA-DR compatibility in clinical renal transplantation.

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