Cinoxacin in therapy of urinary tract infections. Comparison of two dosage regimens

Abstract

TWo dosage regimens of cinoxacin, 250 mg. four times a day (QID) versus 500 mg. twice a day (BID), were compared for efficacy and safety in the treatment of initial and recurrent urinary tract infections. Patient dosage assignments were by a random table. Analysis of the 91 evaluable adult patients showed no difference between the two regimens, each group having 98 per cent bacteriologic cures at the five-to-nine-day post-therapy culture. The incidence of side effects was low and mild in degree.