Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Apr;11(1-2):129-34.
doi: 10.1007/BF01991481.

Histamine in brain capillaries

F Joó, E Dux, I L Karnushina, N Halász, A Gecse, A Ottlecz, Z Mezei

Histamine in brain capillaries

F Joó et al. Agents Actions. 1981 Apr.

Abstract

A high amount of histamine was found in capillaries isolated by subcellular fractionation from the brain. In view of the important effects of histamine on vascular permeability in peripheral vessels, it was thought that histamine had a similar function in the cerebral vasculature. Intracarotic histamine infusion resulted in an enhanced pinocytosis of endothelial cells and te oedematous swelling of the astrocytic end-feet system. [3H]-Histamine, injected in the cerebral ventricles, accumulated in the capillary wall. Histamine and cimetidine activated hydroxyfatty acid and prostaglandin D2 synthesis in isolated brain capillaries. The possible function of the capillary histamine in the regulation of permeability of microvessels is discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Blood Vessels. 1975;12(3):181-91 - PubMed
    1. Brain Res. 1979 May 25;168(2):323-30 - PubMed
    1. Agents Actions. 1979 Apr;9(1):89-90 - PubMed
    1. Experientia. 1972 Dec 15;28(12):1470-1 - PubMed
    1. Experientia. 1975 May 15;31(5):582-4 - PubMed

Publication types