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Clinical Trial
. 1981 Jun;88(6):644-9.
doi: 10.1111/j.1471-0528.1981.tb01223.x.

A double blind trial of extra-amniotic oestriol and prostaglandin F2 alpha gels in cervical ripening

M A Quinn, A J Murphy, R J Kuhn, H P Robinson, J B Brown
Clinical Trial

A double blind trial of extra-amniotic oestriol and prostaglandin F2 alpha gels in cervical ripening

M A Quinn et al. Br J Obstet Gynaecol. 1981 Jun.

Abstract

Forty nulliparous patients with Bishop score of 3 or less were given 15 mg oestriol gel, 10 mg PGF2 alpha gel or gel alone via the extra-amniotic route. Both the oestriol and prostaglandin treated patients had a significant increase in Bishop score and a significant reduction in induction-delivery interval compared to controls. Oestriol gel had significantly less stimulatory effect on uterine activity than prostaglandin gel, indicating a possible local action.

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