Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1978 Oct 1;148(4):1007-19.
doi: 10.1084/jem.148.4.1007.

The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells

K M Morris, H R Colten, D H Bing
Comparative Study

The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells

K M Morris et al. J Exp Med. .

Abstract

Epithelial and mesenchymal cells synthesized and secreted all three subcomponents of the first component of complement (C1): C1q, C1r, and C1s. Quantitatively, however, columnar and transitional epithelial cells secreted 400--3,700 times more hemolytically active C1 than monocytes or fibroblasts. Only columnar epithelial cells synthesized C1 subcomponents with subunit structures similar to their serum counterparts. Transitional epithelial cells, fibroblasts, and monocytes produced C1q and C1s with subunits of apparent molecular weights larger than reported values. C1r from all cell lines was physiochemically similar to serum C1r.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Immunol. 1963 Dec;91:851-8 - PubMed
    1. J Exp Med. 1963 Jun 1;117:983-1008 - PubMed
    1. J Immunol. 1977 May;118(5):1903-5 - PubMed
    1. Biochem J. 1977 Feb 1;161(2):239-45 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Apr;74(4):1707-10 - PubMed

Publication types