Segmental transplantation of the pancreas with and without the ligation of the duct in dogs

Abstract

The autotransplantation of a pancreas segment with ligated duct to cervical vessels, autotransplantation and allotransplantation of a pancreas segment with unligated duct to iliac vessels were carried out in three groups of dogs. The occurrence was followed of the hemorrhagic necrosis and of their complications. When ligating the duct, the mortality and the rate of occurrence of hemorrhagic necrosis were of 54 and 77% respectively. In grafts with an open duct into the abdominal cavity, for the autotransplantation the mortality and occurrence of the hemorrhagic necroses were of 33%, for the allotransplantation the mortality and autodigestion were of 11 and 45%, respectively. The cause of the hemorrhagic necrosis in animals with unligated duct of the graft was most probably represented by a hematoma. The graft rejection was characterized by an asymptotic course without damaging the recipient. The transplantation method with open duct into the abdominal cavity is promising for the clinical application.