Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981;3(2):115-22.
doi: 10.1016/0192-0561(81)90001-1.

Antitumor activity of intralesionally administered Nocardia opaca preparations in rat and mouse tumors: a comparison with BCG and Corynebacterium parvum

R Barot-Ciorbaru, J F Petit, D Chassoux, J C Salomon

Antitumor activity of intralesionally administered Nocardia opaca preparations in rat and mouse tumors: a comparison with BCG and Corynebacterium parvum

R Barot-Ciorbaru et al. Int J Immunopharmacol. 1981.

Abstract

Three Nocardia products: delipidated cells, lysozyme digest and Nocardia Water Soluble Mitogen (NW SM), have been assayed in regression experiments and compared with living BCG and killed C. parvum in rat and mouse fibrosarcomas transplanted intradermally. Intratumor injection of these Nocardia products induced regression in the BCG sensitive McFiFi2 (S) tumor. These substances were active at a dose of 1 mg, the lysozyme extract and NW SM also being active at 0.1 mg. Association with mineral or vegetable oil increased the efficiency of delipidated cells, and under these conditions, regression of tumors implanted contralaterally to treated tumors was also obtained.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources