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. 1981 Mar;13(1 Pt 1):281-5.

Liver transplantation, 1980, with particular reference to cyclosporin-A

T E Starzl, S Iwatsuki, G Klintmalm, G P Schröter, R Weil 3rd, L J Koep, K A Porter

Liver transplantation, 1980, with particular reference to cyclosporin-A

T E Starzl et al. Transplant Proc. 1981 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1
Life survival curves of three successive series of patients who were given orthotopic liver homografts at the University of Colorado.
Fig. 2
Fig. 2
Daily lymph volumes and lymphocytes obtained by TDD in an orthotopic liver recipient whose original hepatic disease was primary biliary cirrhosis.
Fig. 3
Fig. 3
The development of jaundice in the recipient of a cadaveric kidney who was being treated with cyclosporin-A. Note decline of the bilirubin after reduction of the cyclosporin-A dose, but with the penalty of renal homograft rejection. Eventually, the combination of prednisone plus an increased dose of cyclosporin-A allowed control of the rejection.
Fig. 4
Fig. 4
The development of uremia in an orthotopic liver recipient treated with cyclosporin-A. Kidney function returned to normal after a reduction in cyclosporin-A dose. Note that prednisone was given from the beginning, but in rapidly decreasing amounts. Later (not shown), the penalty of decreasing immunosuppression was liver homograft rejection as judged by liver biopsy. An increase of the cyclosporin-A dose plus steroid therapy seemed to control the rejection, but subsequently it was found that the liver homograft was partly constructed. The cholecystojejunostomy was converted to a choledochojejunostomy, with amelioration of the low-grade jaundice.
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References

    1. Starzl TE. Experience in Hepatic Transplantation. Philadelphia: WB Saunders; 1969.
    1. Starzl TE, Koep LJ, Halgrimson CG, et al. Gastroenterology. 1979;77:375. - PMC - PubMed
    1. Calne RY, Williams R. Curr Prob Surg. 1979;16:3. - PubMed
    1. Starzl TE, Koep L, Porter KA, et al. Arch Surg. 1980;115:815–819. - PMC - PubMed
    1. Starzl TE, Weil R, III, Koep LJ, et al. Surg Gynecol Obstet. 1979;149:815. - PMC - PubMed

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