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. 1981 Jul 15;37(7):687-9.
doi: 10.1007/BF01967923.

Irreversible inactivation of yeast glucose-6-P dehydrogenase by penicillin G

P F Han, Y H Mariam, S H Pollock, H W Matthews, J Johnson

Irreversible inactivation of yeast glucose-6-P dehydrogenase by penicillin G

P F Han et al. Experientia. .

Abstract

Yeast glucose-6-P dehydrogenase is irreversibly inactivated by penicillin G. Kinetic data show that 1 molecule of penicillin G reacts with each active unit when the enzyme is inactivated. The rate of inactivation increases greatly with increasing pH. This irreversible inactivation by penicillin G is largely prevented by pyridoxal-P, a reversible inactivator or this enzyme. Prior treatment of penicillin G with penicillinase totally abolishes its ability to inactivate the enzyme.

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References

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