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. 1981 Oct;30(10):879-82.
doi: 10.2337/diab.30.10.879.

Demonstration of glucagon in the stomach of human fetuses

M Ravazzola, R H Unger, L Orci

Demonstration of glucagon in the stomach of human fetuses

M Ravazzola et al. Diabetes. 1981 Oct.

Abstract

Electron microscopy using antiglucagon or antiglicentin antisera and the protein A-gold (pAg) technique revealed a population of immunoreactive cells in the gastric mucosa of human fetuses. The secretory granules of these cells showed the same ultrastructural characteristics and the same labeling pattern as pancreatic alpha-granules. These data demonstrate that the stomach of human fetuses contains cells with secretory granules indistinguishable by morphologic and immunocytochemical criteria from the pancreatic A-cells.

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