[Treatment of hypotension complicating pregnancy improves fetal outcome]

Abstract

A prospective study 30 out of 60 pregnant women suffering from pathologic hypotension were treated regularly with the mineralocorticoid 11-Desoxycorticosteronönanthat (Cortiron (R)-Depot). To the other 30 women no medication was given --they served as a control-group. In order to get information on the uteroplacental perfusion rate, placental flow measurements using radioisotopes were carried out. In comparison with the untreated blood-pressure and placental perfusion in the medicated pregnant women was significantly higher. The investigation of the fetal outcome showed 600 g heavier neonates in the mineralocorticoid treated group; the rate of dystrophy was significantly lower. The results entitle the requirement of medication in cases of maternal hypotension (RR 110/65 mm Hg and below). By our experiences we can recommend the mineralocorticoid Cortiron (R)-Depot.