Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981;65(2):163-6.
doi: 10.1007/BF00929182.

Adoptive transfer of immunity to Plasmodium berghei after busulfan and cyclophosphamide treatment of recipient mice

M V Londner, S Frankenburg, E Tyroler, C L Greenblatt

Adoptive transfer of immunity to Plasmodium berghei after busulfan and cyclophosphamide treatment of recipient mice

M V Londner et al. Z Parasitenkd. 1981.

Abstract

Balb/c mice injected with P. berghei die about 21 days after infection. Successful cell transfer in mice was made possible by the pretreatment of the recipient with a combination of busulfan and cyclophosphamide. Cell counts showed that drug-treated mice contain 20 times less bone marrow cells than normal mice, and when injected with P. berghei die significantly later than normal controls. The animals were injected with normal (NBM) and immune bone marrow and normal (NSp) and immune spleen (ISp). The results obtained showed that ISp lengthens significantly the average survival time, producing cure of 50% of the recipients. Transfer of NSp and NBM also lengthens the average survival time.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Blood. 1974 Jul;44(1):49-56 - PubMed
    1. J Protozool. 1969 Nov;16(4):728-30 - PubMed
    1. Cell Immunol. 1980 Sep 15;55(1):185-90 - PubMed
    1. Infect Immun. 1976 Jul;14(1):184-90 - PubMed
    1. Trans R Soc Trop Med Hyg. 1972;66(6):921-30 - PubMed

Publication types

LinkOut - more resources