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. 1981 Jul;78(7):4458-60.
doi: 10.1073/pnas.78.7.4458.

Localization of the human insulin gene to the distal end of the short arm of chromosome 11

M E Harper, A Ullrich, G F Saunders

Localization of the human insulin gene to the distal end of the short arm of chromosome 11

M E Harper et al. Proc Natl Acad Sci U S A. 1981 Jul.

Abstract

The human insulin gene was mapped by hybridization in situ of 3H-labeled recombinant plasmid pHIG900 to chromosome preparations in the presence of 10% dextran sulfate. pHIG900 contains a 900-base pair insert of human genomic DNA that includes the coding region for the C peptide and intervening sequence 2. A significant percentage of hybridized cells (34%) exhibited silver grains on the distal end of the short arm (band p15) of chromosome 11. Furthermore, silver grains on this region represented 26% of all chromosomal label. These results demonstrate chromosomal localization of the human insulin gene to 11p15.

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