Immunology of sarcomas

Abstract

Tumor antigens have now been demonstrated for most experimentally induced tumors by in vivo transplantation techniques, but the demonstration of antigens unique to human tumors has depended on in vitro methods. We have reviewed 1) the evidence that experimental sarcomas express tumor-specific transplantation antigens and that responses against these antigens can be protective in vivo; 2) the in vitro evidence for the existence to antigens associated with sarcomas; and 3) the use of cell hybridization techniques to produce monoclonal antibody to define the distribution of cell surface antigens expressed by human sarcoma cells.