[Fenquizone in the medium term treatment of essential hypertension. Double-blind comparison with chlorthalidone and placebo]

Abstract

In a double blind study, tolerability and antihypertensive effect of fenquizone were compared with those of chlorthalidone and placebo. In both mild and moderately severe essential hypertension, fenquizone and chlortalidone showed a significant antihypertensive effect; moreover, fenquizone lowered the clinostatic arterial diastolic pressure in a more gradual and continuous way. Differently from chlortalidone, fenquizone had no effects on blood levels of potassium and cholesterol.