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. 1981 Aug;78(8):4669-73.
doi: 10.1073/pnas.78.8.4669.

Translational regulation: identification of the site on bacteriophage T4 rIIB mRNA recognized by the regA gene function

J Karam, L Gold, B S Singer, M Dawson

Translational regulation: identification of the site on bacteriophage T4 rIIB mRNA recognized by the regA gene function

J Karam et al. Proc Natl Acad Sci U S A. 1981 Aug.

Abstract

The bacteriophage T4 gene regA encodes a protein that diminishes the expression of many unlinked early T4 genes. Previous work demonstrated that regA-mediated repression occurs after transcription. We report here on the identification of the target site on one regA-sensitive mRNA, the message encoding the phage T4 rIIB protein. The target for regA-mediated action overlaps the translational initiation domain of the rIIB messenger. The regA protein may be a repressor that operates translationally on a significant and interesting set of early phage T4 mRNAs.

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References

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