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. 1981 Aug;78(8):5147-50.
doi: 10.1073/pnas.78.8.5147.

Human trophoblast cell-surface antigens defined by monoclonal antibodies

M Lipinski, D R Parks, R V Rouse, L A Herzenberg

Human trophoblast cell-surface antigens defined by monoclonal antibodies

M Lipinski et al. Proc Natl Acad Sci U S A. 1981 Aug.

Abstract

A series of monoclonal antibodies has been raised against the human choriocarcinoma cell-line, BeWo. Four antigens, Trop-1, -2, -3, and -4, are defined on normal and malignant trophoblast cells. Trop-1 and Trop-2 appear to be specifically expressed on syncytio- and cytotrophoblasts, whereas Trop-3 and Trop-4 are also detected on various tumor cell lines, normal lymphocytes, and monocytes. Anti-Trop-1 and anti-Trop-2 antibodies might prove useful for detection and isolation of fetal trophoblast cells circulating in pregnant women's blood and for diagnosis and therapy in patients having choriocarcinomas and other germ-cell neoplasms.

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References

    1. Proc Natl Acad Sci U S A. 1979 Apr;76(4):1962-6 - PubMed
    1. J Immunol. 1979 Jun;122(6):2508-15 - PubMed
    1. Prenat Diagn. 1981 Jan;1(1):61-73 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1453-5 - PubMed
    1. J Pathol Bacteriol. 1958 Apr;75(2):257-65 - PubMed

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