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. 1981 Sep;78(9):5778-82.
doi: 10.1073/pnas.78.9.5778.

Mitotic chromosome loss in a radiation-sensitive strain of the yeast Saccharomyces cerevisiae

R K Mortimer, R Contopoulou, D Schild

Mitotic chromosome loss in a radiation-sensitive strain of the yeast Saccharomyces cerevisiae

R K Mortimer et al. Proc Natl Acad Sci U S A. 1981 Sep.

Abstract

Cells of Saccharomyces cerevisiae with mutations in the RAD52 gene have previously been shown to be defective in meiotic and mitotic recombination, in sporulation, and in repair of radiation-induced damage to DNA. In this study we show that diploid cells homozygous for rad52 lose chromosomes at high frequencies and that these frequencies of loss can be increased dramatically by exposure of these cells to x-rays. Genetic analyses of survivors of x-ray treatment demonstrate that chromosome loss events result in the conversion of diploid cells to cells with near-haploid chromosome numbers.

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References

    1. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1377-81 - PubMed
    1. Genetics. 1978 Apr;88(4 Pt 1):651-71 - PubMed
    1. Annu Rev Genet. 1976;10:53-134 - PubMed
    1. Mutat Res. 1981 Feb;80(2):281-7 - PubMed
    1. Mutat Res. 1974 Sep;24(3):281-92 - PubMed

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