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. 1982 Jan;149(1):294-8.
doi: 10.1128/jb.149.1.294-298.1982.

DNA sequence fine-structure analysis of ilvG (IlvG+) mutations of Escherichia coli K-12

R P Lawther, D H Calhoun, J Gray, C W Adams, C A Hauser, G W Hatfield

DNA sequence fine-structure analysis of ilvG (IlvG+) mutations of Escherichia coli K-12

R P Lawther et al. J Bacteriol. 1982 Jan.

Abstract

Six ilvG (IlvG+) mutations of Escherichia coli K-12 were transferred to recombinant plasmids, and the DNA sequence of each mutation was determined. This analysis confirmed that expression of the ilvG gene product (acetohydroxy acid synthase II) requires the deletion of a single base pair or the addition of two base pairs within ilvG to displace a frameshift site present in wild-type E. coli K-12. This system should be useful in the analysis of potential frameshift mutagens.

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