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. 1981 Oct-Dec;18(4):357-63.
doi: 10.1007/BF02042820.

Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect

P Tessari, A Meneghel, A Avogaro, E Duner, S Del Prato, M Tuzzato, A Tiengo

Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect

P Tessari et al. Acta Diabetol Lat. 1981 Oct-Dec.

Abstract

Mitochondrial glycerophosphate-acetyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats, A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10(-5) M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity.

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