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Clinical Trial
. 1981 Dec:38 Suppl 1:867-73.

[Clofibrate for the treatment of hyperbilirubinemia in neonates born at term: a double blind controlled study (author's transl)]

[Article in French]
A Lindenbaum, X Hernandorena, M Vial, C Benattar, J C Janaud, M Dehan, A Foliot, R Leluc, J C Gabilan
  • PMID: 7036932
Clinical Trial

[Clofibrate for the treatment of hyperbilirubinemia in neonates born at term: a double blind controlled study (author's transl)]

[Article in French]
A Lindenbaum et al. Arch Fr Pediatr. 1981 Dec.

Abstract

A double blind controlled study of the therapeutic effect of clofibrate, an inductor of bilirubin glucuronyl transferase, was performed in neonates born at term and presenting with physiologic jaundice. 47 children were treated with a single oral dose of clofibrate. 46 control children were given corn oil alone. Results show that mean plasma bilirubin levels are significantly lower in the treated group as compared with the control group, from the 16th hour of treatment, if there is no ABO incompatibility. Clofibrate treatment also resulted in a shorter duration of jaundice and a restricted use of phototherapy. No undesirable side-effect was observed.

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