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. 1982:7:643-5.

Suppression of natural tumor resistance by tumor promoters

  • PMID: 7039836

Suppression of natural tumor resistance by tumor promoters

R Keller et al. Carcinog Compr Surv. 1982.

Abstract

The findings of the present and other studies (4,7) show that TPA and other tumor-promoting esters suppress various in vitro manifestations of natural cell-mediated tumor resistance: (a) prevention of enhancement of macrophage cytocidal activity; (b) suppression of cytocidal capacity by activated macrophages; and (c) suppression of cytolytic activity of NK cells. Moreover, they abrogate host tumor resistance in vivo. These suppressive effects of tumor promoters on natural antitumor effector systems may constitute a fundamental mechanism in carcinogenesis.

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