Sources and biology of regulatory factors active on mouse myeloid leukemic cells
- PMID: 7040419
- DOI: 10.1002/jcp.1041130425
Sources and biology of regulatory factors active on mouse myeloid leukemic cells
Abstract
The action of serum or cells in enforcing differentiation in mouse myelomonocytic leukemic cells was monitored in agar cultures of WEHI-3B leukemic cells. The repeated intravenous injection of 5 micrograms endotoxin initially increased serum differentiating activity but after the third injection responses to further injections decreased markedly. Congenitally athymic (nude) mice exhibited normal rises in serum differentiating activity when injected with endotoxin but C3H HeJ mice failed to respond to challenge with purified lipid A. Whole body irradiation up to 1,200 rads did not increase serum differentiating activity but did not suppress responses to challenge injection of endotoxin. Coculture of WEHI-3B cells with peritoneal cells from normal or irradiated BALB/c mice caused marked granulocytic differentiation in WEHI-3B colonies. This effect was not seen if leukemic cells were cultured with thymus, spleen, or bone marrow cells. The serum halflife of the factor in postendotoxin serum enforcing differentiation of WEHI-3B cells was shown to be 1.5-2.3 hr.
Similar articles
-
Characterization of a serum factor stimulating the differentiation of myelomonocytic leukemic cells.Int J Cancer. 1980 Nov 15;26(5):647-54. doi: 10.1002/ijc.2910260517. Int J Cancer. 1980. PMID: 6972358
-
Clonal extinction of myelomonocytic leukemic cells by serum from mice injected with endotoxin.Int J Cancer. 1980 Feb 15;25(2):225-33. doi: 10.1002/ijc.2910250210. Int J Cancer. 1980. PMID: 6967053
-
Synthesis by mouse peritoneal cells of G-CSF, the differentiation inducer for myeloid leukemia cells: stimulation by endotoxin, M-CSF and multi-CSF.Leuk Res. 1985;9(1):35-50. doi: 10.1016/0145-2126(85)90020-7. Leuk Res. 1985. PMID: 3887043
-
G-CSF: its relationship to leukemia differentiation-inducing activity and other hemopoietic regulators.J Cell Physiol Suppl. 1982;1:53-64. doi: 10.1002/jcp.1041130411. J Cell Physiol Suppl. 1982. PMID: 6802860
-
In vitro approaches to lymphopoiesis, hemopoiesis, and oncogenesis.Kroc Found Ser. 1984;18:293-307. Kroc Found Ser. 1984. PMID: 6152287 Review.
Cited by
-
Local and metastatic growth and in vivo differentiation of human myeloid leukemia cells transplanted in nude mice.Virchows Arch A Pathol Anat Histopathol. 1984;403(1):41-57. doi: 10.1007/BF00689337. Virchows Arch A Pathol Anat Histopathol. 1984. PMID: 6326381
-
The in vivo functions and properties of persisting cell-stimulating factor.Immunology. 1984 Sep;53(1):33-42. Immunology. 1984. PMID: 6432685 Free PMC article.
-
Some properties of Bomirski Ab amelanotic melanoma cells, which underwent spontaneous melanization in primary cell culture. Growth kinetics, cell morphology, melanin content and tumorigenicity.J Cancer Res Clin Oncol. 1985;109(1):29-37. doi: 10.1007/BF01884251. J Cancer Res Clin Oncol. 1985. PMID: 3972882 Free PMC article.
-
Induced differentiation of avian myeloblastosis virus-transformed myeloblasts: phenotypic alteration without altered expression of the viral oncogene.Mol Cell Biol. 1984 Dec;4(12):2587-93. doi: 10.1128/mcb.4.12.2587-2593.1984. Mol Cell Biol. 1984. PMID: 6098812 Free PMC article.
-
Antileukemic effect of alkyl phospholipids. I. Inhibition of proliferation and induction of differentiation of cultured myeloid leukemia cells by alkyl ethyleneglycophospholipids.Cancer Chemother Pharmacol. 1983;11(2):73-6. doi: 10.1007/BF00254248. Cancer Chemother Pharmacol. 1983. PMID: 6578882
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Other Literature Sources