Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Apr;69(4):452-4.

Serum penicillin concentrations after intramuscular administration of benzathine penicillin G in children

C M Ginsburg, G H McCracken Jr, T C Zweighaft
  • PMID: 7041073

Serum penicillin concentrations after intramuscular administration of benzathine penicillin G in children

C M Ginsburg et al. Pediatrics. 1982 Apr.

Abstract

Concentrations of penicillin were measured in serum samples of 26 children who received benzathine penicillin G (BPG) alone or in combination with procaine penicillin (PBPG). Both preparations were well absorbed; peak concentrations of penicillin after PBPG administration were 25-fold larger than those after BPG. One third and one half of serum samples from BPG and PBPG patients, respectively, contained no measurable penicillin activity at 18 days. At 30 days, there was no penicillin activity in any of the samples. These data raise questions regarding the use of BPG and PBPG for prophylaxis of group A streptococcal and pneumococcal infections.

PubMed Disclaimer

Publication types

Substances